We are proud to announce the publication of a comprehensive review article by lab alumnus Dr. Jonathan Ram in Essays in Biochemistry.
In the article, titled “The many faces of p97/Cdc48 in mitochondrial homeostasis,” Dr. Ram provides an integrated overview of the critical AAA+ ATPase p97. The review highlights p97 as a central hub that coordinates essential cellular processes to maintain mitochondrial health, including:
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Protein Quality Control: regulating mitochondria-associated degradation (MAD) pathways.
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Mitochondrial Dynamics: influencing fusion, fission, and mitophagy.
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Cell Fate: orchestrating apoptotic signaling.
Understanding these diverse “faces” of p97 is crucial, as its dysfunction is linked to severe multisystem degenerative disorders.