Publications

Featured Publications:

Maniv I, Sarji M, Bdarneh A, Feldman A, Ankawa R, Koren E, Magid-Gold I, Reis N, Soteriou D, Salomon-Zimri S, Lavy T, Kesselman E, Koifman N, Kurz T, Kleifeld O, Michaelson D, van Leeuwen FW, Verheijen BM, Fuchs Y, Glickman MH. Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model. Nat Commun. 2023 Sep 22;14(1):5922. doi: 10.1038/s41467-023-41545-7.

 

Sahu I, Mali SM, Sulkshane P, Xu C, Rozenberg A, Morag R, Sahoo MP, Singh SK, Ding Z, Wang Y, Day S, Cong Y, Kleifeld O, Brik A, Glickman MH. The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag. Nat Commun. 2021 Oct 26;12(1):6173. doi: 10.1038/s41467-021-26427-0.

Sulkshane P, Ram J, Thakur A, Reis N, Kleifeld O, Glickman MH. Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Redox Biol. 2021 Sep;45:102047. doi: 10.1016/j.redox.2021.102047.

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Michal Chojnacki, Wissam Mansour, Dharjath S. Hameed, Rajesh Singh, Rina Rosenzweig, Mark A. Nakasone, Farid El Oualid, Zanlin Yu, Fabian Glaser, Lewis E. Kay, David Fushman, Huib Ovaa and Michael H. Glickman. Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit. Cell Chemical Biology 2017 24, 1–15 April 20, http://dx.doi.org/10.1016/j.chembiol.2017.02.013. http://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30061-2.

 

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Sumeet K. Singh, Indrajit Sahu, Sachitanand M. Mali, Hosahalli P. Hemantha, Oded Kliefeld, Michael H. Glickman, and Ashraf Brik. Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin. J. Am. Chem. Soc., December 6, 2016 (Article) DOI:10.1021/jacs.6b09611 http://pubs.acs.org/doi/full/10.1021/jacs.6b09611

 

Mayor T, Sharon M, Glickman M. H.Tuning the proteasome to brighten the end of the journey. Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C793-C804. doi: 10.1152/ajpcell.00198.2016. Epub 2016 Sep 7. http://ajpcell.physiology.org/content/311/5/C793.long

Keren-Kaplan T, Zeev Peters L, Levin-Kravets O, Attali I, Kleifeld O, Shohat N, Artzi S, Zucker O, Pilzer I, Reis N, Glickman M.H, Ben-Aroya S, Prag G.   Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism. Nature Communications. 2016 Oct 4;7:12960. doi: 10.1038/ncomms12960. https://www.nature.com/articles/ncomms12960

Hjerpe R, Bett J.S, Keuss M.J, Solovyova A, McWilliams T.G, Johnson C, Sahu I, Varghese J, Wood N, Wightman M, Osbourne G, Bates G.P, Glickman M.H, Trost M, Knebel A, Marchesi F, and Kurz T. (2016). UBQLN2 connects the proteasome with the HSP70 system to promote autophagy-independent protein aggregate clearance. Cell, Vol. 166, 1–15, August 11, 2016http://www.cell.com/cell/fulltext/S0092-8674(16)30866-2