Featured Publications:

Sahu I and Glickman MH. Proteasome in action: substrate degradation by the 26S proteasome. Biochem Soc Trans. 2021 Mar 17:BST20200382. doi: 10.1042/BST20200382

Sulkshane P, Duek I, Ram J, Thakur A, Reis N, Ziv T, and Michael H. Glickman. Inhibition of Proteasome reveals basal mitochondrial ubiquitination.                        J Proteomics. 2020 Aug 31;229:103949. doi: 10.1016/j.jprot.2020.103949.

PowerPoint Presentation

Michal Chojnacki, Wissam Mansour, Dharjath S. Hameed, Rajesh Singh, Rina Rosenzweig, Mark A. Nakasone, Farid El Oualid, Zanlin Yu, Fabian Glaser, Lewis E. Kay, David Fushman, Huib Ovaa and Michael H. Glickman. Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit. Cell Chemical Biology 2017 24, 1–15 April 20,



Sumeet K. Singh, Indrajit Sahu, Sachitanand M. Mali, Hosahalli P. Hemantha, Oded Kliefeld, Michael H. Glickman, and Ashraf Brik. Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin. J. Am. Chem. Soc., December 6, 2016 (Article) DOI:10.1021/jacs.6b09611


Mayor T, Sharon M, Glickman M. H.Tuning the proteasome to brighten the end of the journey. Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C793-C804. doi: 10.1152/ajpcell.00198.2016. Epub 2016 Sep 7.

Keren-Kaplan T, Zeev Peters L, Levin-Kravets O, Attali I, Kleifeld O, Shohat N, Artzi S, Zucker O, Pilzer I, Reis N, Glickman M.H, Ben-Aroya S, Prag G.   Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism. Nature Communications. 2016 Oct 4;7:12960. doi: 10.1038/ncomms12960.

Hjerpe R, Bett J.S, Keuss M.J, Solovyova A, McWilliams T.G, Johnson C, Sahu I, Varghese J, Wood N, Wightman M, Osbourne G, Bates G.P, Glickman M.H, Trost M, Knebel A, Marchesi F, and Kurz T. (2016). UBQLN2 connects the proteasome with the HSP70 system to promote autophagy-independent protein aggregate clearance. Cell, Vol. 166, 1–15, August 11, 2016