Our group mainly focuses on Ubiquitin proteasome System (UPS) research and its contribution towards neurodisorders.
Our lab hope to gain insight into the cellular system that degrades proteins in a controlled manner. This system ensures that superfluous or defective proteins are marked with a molecular tag, the protein ubiquitin, and are disposed of in the cellular shredding machine, the proteasome. The ubiquitin-proteasome system is found in all eukaryotic cells and is – as its name indicates – ubiquitous. It is one of the organism’s most complex cellular systems and protects the body against serious diseases. For example, defective proteins that elude this system trigger serious diseases such as Alzheimer’s, Parkinson’s, Huntington’s, cystic fibrosis or diabetes.